Your browser doesn't support javascript.
loading
Predictors of anemia and iron status at birth in neonates born to women carrying multiple fetuses.
Ru, Yuan; Pressman, Eva K; Guillet, Ronnie; Katzman, Philip J; Bacak, Stephen J; O'Brien, Kimberly O.
Afiliação
  • Ru Y; Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA.
  • Pressman EK; The University of Rochester School of Medicine, Rochester, NY, USA.
  • Guillet R; The University of Rochester School of Medicine, Rochester, NY, USA.
  • Katzman PJ; The University of Rochester School of Medicine, Rochester, NY, USA.
  • Bacak SJ; Department of Maternal-Fetal Medicine, Akron Children's Hospital, Akron, OH, USA.
  • O'Brien KO; Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA. koo4@cornell.edu.
Pediatr Res ; 84(2): 199-204, 2018 08.
Article em En | MEDLINE | ID: mdl-29907852
BACKGROUND: Iron (Fe) status of neonates born to women carrying multiple fetuses might be compromised as a consequence of the high prevalence of maternal Fe deficiency and anemia coupled with an increased risk of preterm birth. This study aimed to characterize and identify determinants of anemia in this neonatal population. METHODS: Umbilical cord blood obtained from 183 neonates was utilized to assess hemoglobin (Hb), ferritin (SF), soluble transferrin receptor (sTfR), hepcidin, serum Fe, erythropoietin, folate, vitamin B-12, C-reactive protein, and interleukin-6. Associations with maternal Fe status were explored. RESULTS: Cord Hb or SF did not change significantly as a function of gestational age at birth (25-38 wks). Neonates born to women who were obese prior to pregnancy or smoked cigarettes during pregnancy had a 4-5-fold greater odds of anemia at birth. Cord sTfR was the strongest indicator of cord Hb (P < 0.0001), and it was significantly associated with maternal sTfR at mid-gestation (P = 0.01) and delivery (P = 0.002). Cord Fe indicators were significantly associated with cord hepcidin, but not maternal hepcidin. CONCLUSION: Screening for Fe status in neonates born to women carrying multiple fetuses is warranted, especially for those born to smokers or to women who are obese at entry into pregnancy.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Gravidez Múltipla / Anemia Ferropriva / Doenças do Recém-Nascido / Anemia / Ferro Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Newborn / Pregnancy Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Gravidez Múltipla / Anemia Ferropriva / Doenças do Recém-Nascido / Anemia / Ferro Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Newborn / Pregnancy Idioma: En Ano de publicação: 2018 Tipo de documento: Article