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Reduced plasma concentration of branched-chain amino acids in sarcopenic older subjects: a cross-sectional study.
Ottestad, Inger; Ulven, Stine M; Øyri, Linn K L; Sandvei, Kristin S; Gjevestad, Gyrd O; Bye, Asta; Sheikh, Navida A; Biong, Anne S; Andersen, Lene F; Holven, Kirsten B.
Afiliação
  • Ottestad I; 1Department of Nutrition,Institute of Basic Medical Sciences,University of Oslo,PO Box 1046,Blindern,0317 Oslo,Norway.
  • Ulven SM; 1Department of Nutrition,Institute of Basic Medical Sciences,University of Oslo,PO Box 1046,Blindern,0317 Oslo,Norway.
  • Øyri LKL; 1Department of Nutrition,Institute of Basic Medical Sciences,University of Oslo,PO Box 1046,Blindern,0317 Oslo,Norway.
  • Sandvei KS; 1Department of Nutrition,Institute of Basic Medical Sciences,University of Oslo,PO Box 1046,Blindern,0317 Oslo,Norway.
  • Gjevestad GO; 1Department of Nutrition,Institute of Basic Medical Sciences,University of Oslo,PO Box 1046,Blindern,0317 Oslo,Norway.
  • Bye A; 2Department of Nursing and Health Promotion, Faculty of Health Sciences,Oslo and Akershus University College of Applied Sciences,PO Box 4,St. Olavs plass,0130 Oslo,Norway.
  • Sheikh NA; 2Department of Nursing and Health Promotion, Faculty of Health Sciences,Oslo and Akershus University College of Applied Sciences,PO Box 4,St. Olavs plass,0130 Oslo,Norway.
  • Biong AS; 4Centre for Research and Development,TINE SA,PO Box 7,Kalbakken,0902 Oslo,Norway.
  • Andersen LF; 1Department of Nutrition,Institute of Basic Medical Sciences,University of Oslo,PO Box 1046,Blindern,0317 Oslo,Norway.
  • Holven KB; 1Department of Nutrition,Institute of Basic Medical Sciences,University of Oslo,PO Box 1046,Blindern,0317 Oslo,Norway.
Br J Nutr ; 120(4): 445-453, 2018 08.
Article em En | MEDLINE | ID: mdl-29909813
Branched-chain amino acids (BCAA) are essential amino acids that are necessary for muscle mass maintenance. Little is known about the plasma concentrations of BCAA and the protein intake in relation to sarcopenia. We aimed to compare the non-fasting plasma concentrations of the BCAA and the dietary protein intake between sarcopenic and non-sarcopenic older adults. Norwegian older home-dwelling adults (≥70 years) were invited to a cross-sectional study with no other exclusion criteria than age. Sarcopenic subjects were defined by the diagnostic criteria by the European Working Group on Sarcopenia in Older People. Non-fasting plasma concentrations of eight amino acids were quantified using NMR spectroscopy. Protein intake was assessed using 2×24-h dietary recalls. In this study, ninety out of 417 subjects (22 %) were sarcopenic, and more women (32 %) than men (11 %) were sarcopenic (P<0·0001). Sex-adjusted non-fasting plasma concentrations of leucine and isoleucine, and the absolute intake of protein (g/d), were significantly lower among the sarcopenic subjects, when compared with non-sarcopenic subjects (P=0·003, P=0·026 and P=0·003, respectively). A similar protein intake was observed in the two groups when adjusted for body weight (BW) and sex (1·1 g protein/kg BW per d; P=0·50). We show that sarcopenia is associated with reduced non-fasting plasma concentration of the BCAA leucine and isoleucine, and lower absolute intake of protein. More studies are needed to clarify the clinical relevance of these findings, related to maintenance of muscle mass and prevention of sarcopenia.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sarcopenia / Aminoácidos de Cadeia Ramificada Tipo de estudo: Clinical_trials / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male País como assunto: Europa Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sarcopenia / Aminoácidos de Cadeia Ramificada Tipo de estudo: Clinical_trials / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male País como assunto: Europa Idioma: En Ano de publicação: 2018 Tipo de documento: Article