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A CRISPR screen identifies MAPK7 as a target for combination with MEK inhibition in KRAS mutant NSCLC.
Dompe, Nicholas; Klijn, Christiaan; Watson, Sara A; Leng, Katherine; Port, Jenna; Cuellar, Trinna; Watanabe, Colin; Haley, Benjamin; Neve, Richard; Evangelista, Marie; Stokoe, David.
Afiliação
  • Dompe N; Department of Discovery Oncology, Genentech Inc., South San Francisco, CA, United States of America.
  • Klijn C; Department of Bioinformatics, Genentech Inc., South San Francisco, CA, United States of America.
  • Watson SA; Department of Discovery Oncology, Genentech Inc., South San Francisco, CA, United States of America.
  • Leng K; Department of Discovery Oncology, Genentech Inc., South San Francisco, CA, United States of America.
  • Port J; Department of Discovery Oncology, Genentech Inc., South San Francisco, CA, United States of America.
  • Cuellar T; Department of Molecular Biology, Genentech Inc., South San Francisco, CA, United States of America.
  • Watanabe C; Department of Bioinformatics, Genentech Inc., South San Francisco, CA, United States of America.
  • Haley B; Department of Molecular Biology, Genentech Inc., South San Francisco, CA, United States of America.
  • Neve R; Department of Discovery Oncology, Genentech Inc., South San Francisco, CA, United States of America.
  • Evangelista M; Department of Discovery Oncology, Genentech Inc., South San Francisco, CA, United States of America.
  • Stokoe D; Department of Discovery Oncology, Genentech Inc., South San Francisco, CA, United States of America.
PLoS One ; 13(6): e0199264, 2018.
Article em En | MEDLINE | ID: mdl-29912950
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Biomarcadores Tumorais / Proteínas Proto-Oncogênicas p21(ras) / Carcinoma Pulmonar de Células não Pequenas / Proteína Quinase 7 Ativada por Mitógeno Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Biomarcadores Tumorais / Proteínas Proto-Oncogênicas p21(ras) / Carcinoma Pulmonar de Células não Pequenas / Proteína Quinase 7 Ativada por Mitógeno Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article