Salmonid melanin-concentrating hormone inhibits corticotrophin release.
J Endocrinol
; 106(2): R5-8, 1985 Aug.
Article
em En
| MEDLINE
| ID: mdl-2991410
ABSTRACT
Melanin-concentrating hormone (MCH) is a neural peptide associated with colour change in fishes. We show here that it also inhibits corticotrophin (ACTH) secretion. Synthetic salmonid MCH at a concentration of 100pmol/l reduced the in-vitro release of ACTH by pars distales (pDs) taken from stressed trout. At lower concentrations (10pmol/l) the peptide inhibited CRF-41-induced secretion of ACTH by pDs removed from unstressed trout, while at higher concentrations (10nmol/l) it reduced the corticotrophic response of rat pituitary tissue to CRF-41.
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Base de dados:
MEDLINE
Assunto principal:
Hormônios Hipofisários
/
Hormônio Adrenocorticotrópico
/
Hormônios
/
Hormônios Hipotalâmicos
/
Melaninas
/
Melanóforos
Limite:
Animals
Idioma:
En
Ano de publicação:
1985
Tipo de documento:
Article