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Huntington's disease: two families with differing clinical features show linkage to the G8 probe.
Science ; 229(4715): 776-9, 1985 Aug 23.
Article em En | MEDLINE | ID: mdl-2992086
ABSTRACT
To test the hypothesis that interfamily variability in Huntington's Disease (HD) is due to mutation at different loci, linkage analysis was undertaken in two large HD kindreds that differed in ethnicity, age-at-onset, and neurologic and psychiatric features. Both families showed linkage of the HD locus to the G8 probe. Several recombinants were documented in each family, and the best estimate of the recombination fraction for the two families was 6 percent with a 95 percent confidence interval of 0 to 12 percent. Although the data support the existence of a single HD locus, use of the G8 probe for presymptomatic testing in these kindreds would have resulted in a 12 percent error rate in genotype assignment at the HD locus.
Assuntos
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Base de dados: MEDLINE Assunto principal: Cromossomos Humanos 4-5 / Doença de Huntington Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Ano de publicação: 1985 Tipo de documento: Article
Buscar no Google
Base de dados: MEDLINE Assunto principal: Cromossomos Humanos 4-5 / Doença de Huntington Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Ano de publicação: 1985 Tipo de documento: Article