Modulation of cortical responses by transcranial direct current stimulation of dorsolateral prefrontal cortex: A resting-state EEG and TMS-EEG study.
Brain Stimul
; 11(5): 1024-1032, 2018.
Article
em En
| MEDLINE
| ID: mdl-29921529
ABSTRACT
BACKGROUND:
Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique with potential for cost-effective therapeutic neuromodulation. Although positive therapeutic effects were found by stimulating the dorsolateral prefrontal cortex (DLPFC), few studies have investigated physiological effects of DLPFC-tDCS.OBJECTIVES:
To investigate effects of tDCS with different parameter settings applied to the left DLPFC on cortical responses, measured by resting-state electroencephalography (rs-EEG) and transcranial magnetic stimulation (TMS)-evoked/induced EEG responses.METHODS:
22 healthy subjects underwent 5 tDCS sessions with different tDCS parameter settings in a double-blinded randomized crossover design (1 1.5â¯mA, anode left-DLPFC, cathode right-DLPFC; 2 1.5â¯mA, cathode left-DLPFC, anode right-DLPFC; 3 0.5â¯mA, anode left-DLPFC, cathode right-DLPFC; 4 1.5â¯mA, anode left-DLPFC, cathode left deltoid muscle; 5 sham stimulation). Rs-EEG and TMS-EEG were recorded before and after tDCS.RESULTS:
Rs-EEG power spectrum analysis showed no difference comparing baseline with post stimulation in any of the tDCS conditions. TMS-EEG evoked potential amplitude decreased in parietal cortex after 1.5â¯mA left-DLPFC anodal tDCS, and TMS-induced gamma and theta oscillations decreased after all conditions using left-DLPFC anodal tDCS. Left-DLPFC cathodal tDCS did not lead to significant change. None of the post-intervention changes was different when comparing the effects across conditions, including sham.CONCLUSIONS:
Our study does not provide evidence that a single tDCS session results in significant changes in rs-EEG, using the current stimulation parameters. Significant changes in EEG responses to TMS pulses were observed following the anodal 1.5â¯mA tDCS interventions, although these changes were not statistically significant in a group comparison.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Descanso
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Córtex Pré-Frontal
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Eletroencefalografia
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Estimulação Magnética Transcraniana
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Ondas Encefálicas
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Estimulação Transcraniana por Corrente Contínua
Tipo de estudo:
Clinical_trials
Limite:
Adolescent
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Adult
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article