Laminating the mammalian cortex during development: cell polarity protein function and Hippo signaling.
Genes Dev
; 32(11-12): 740-741, 2018 06 01.
Article
em En
| MEDLINE
| ID: mdl-29921662
ABSTRACT
During mammalian brain development, radial glial progenitors balance between proliferation and differentiation to generate the laminated cortical layers in a temporally precise fashion. Defects in the individual steps going into this complex organogenesis can result in cortical malformations and human nervous system disorders. In this issue of Genes & Development, Liu and colleagues (pp. 763-780) present experimental evidence that an evolutionarily conserved cellular polarity gene, Pard3 (partitioning-defective 3), controls the balance of radial glial proliferation and differentiation through interaction with the Hippo signal transduction pathway. Conditional deletion of Pard3 in the developing rodent cortex resulted in striking subcortical band heterotopia, reminiscent of a severe form of human cortical malformation.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Polaridade Celular
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article