Inhibition of the adenosine A2a receptor modulates expression of T cell coinhibitory receptors and improves effector function for enhanced checkpoint blockade and ACT in murine cancer models.

Leone, Robert D; Sun, Im-Meng; Oh, Min-Hee; Sun, Im-Hong; Wen, Jiayu; Englert, Judson; Powell, Jonathan D

Leone, Robert D; Sun, Im-Meng; Oh, Min-Hee; Sun, Im-Hong; Wen, Jiayu; Englert, Judson; Powell, Jonathan D.

Afiliação

Leone RD; Department of Oncology, Sidney-Kimmel Comprehensive Cancer Research Center, Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Sun IM; Department of Oncology, Sidney-Kimmel Comprehensive Cancer Research Center, Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Oh MH; Department of Oncology, Sidney-Kimmel Comprehensive Cancer Research Center, Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Sun IH; Department of Oncology, Sidney-Kimmel Comprehensive Cancer Research Center, Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Wen J; Department of Oncology, Sidney-Kimmel Comprehensive Cancer Research Center, Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Englert J; Department of Oncology, Sidney-Kimmel Comprehensive Cancer Research Center, Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Powell JD; MedImmune, LLC, Gaithersburg, MD, 20878, USA.

Cancer Immunol Immunother ; 67(8): 1271-1284, 2018 Aug.

Article em En | MEDLINE | ID: mdl-29923026

Assuntos

Antagonistas do Receptor A2 de Adenosina/farmacologia; Neoplasias do Colo/tratamento farmacológico; Regulação Neoplásica da Expressão Gênica; Melanoma Experimental/tratamento farmacológico; Receptor de Morte Celular Programada 1/antagonistas & inibidores; Receptor A2A de Adenosina/química; Receptores de Antígenos de Linfócitos T/metabolismo; Animais; Antígenos CD/química; Antígenos CD/metabolismo; Linfócitos T CD8-Positivos/imunologia; Neoplasias do Colo/imunologia; Neoplasias do Colo/metabolismo; Neoplasias do Colo/patologia; Feminino; Imunoterapia; Linfócitos do Interstício Tumoral; Masculino; Melanoma Experimental/imunologia; Melanoma Experimental/metabolismo; Melanoma Experimental/patologia; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Endogâmicos C57BL; Receptor de Morte Celular Programada 1/metabolismo; Linfócitos T Reguladores/imunologia; Células Tumorais Cultivadas; Microambiente Tumoral; Ensaios Antitumorais Modelo de Xenoenxerto; Proteína do Gene 3 de Ativação de Linfócitos

Palavras-chave

A2a; Immune checkpoint; Immunotherapy; Lag-3; PD-1; Treg

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Melanoma Experimental / Receptores de Antígenos de Linfócitos T / Regulação Neoplásica da Expressão Gênica / Neoplasias do Colo / Receptor A2A de Adenosina / Antagonistas do Receptor A2 de Adenosina / Receptor de Morte Celular Programada 1 Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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