Thymic tolerance as a key brake on autoimmunity.
Nat Immunol
; 19(7): 659-664, 2018 07.
Article
em En
| MEDLINE
| ID: mdl-29925986
ABSTRACT
Although the thymus has long been recognized as a key organ for T cell selection, the intricate details linking these selection events to human autoimmunity have been challenging to decipher. Over the last two decades, there has been rapid progress in understanding the role of thymic tolerance mechanisms in autoimmunity through genetics. Here we review some of the recent progress in understanding key thymic tolerance processes that are critical for preventing autoimmune disease.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Timo
/
Autoimunidade
/
Tolerância Imunológica
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article