Synthesis of 3-Methylidene-1-tosyl-2,3-dihydroquinolin-4(1H)-ones as Potent Cytotoxic Agents.

Koszuk, Jacek; Bartosik, Tomasz; Wojciechowski, Jakub; Wolf, Wojciech M; Janecka, Anna; Drogosz, Joanna; Dlugosz, Angelika; Krajewska, Urszula; Mirowski, Marek; Janecki, Tomasz

Koszuk, Jacek; Bartosik, Tomasz; Wojciechowski, Jakub; Wolf, Wojciech M; Janecka, Anna; Drogosz, Joanna; Dlugosz, Angelika; Krajewska, Urszula; Mirowski, Marek; Janecki, Tomasz.

Afiliação

Koszuk J; Institute of Organic Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924, Lódz, Poland.
Bartosik T; Institute of Organic Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924, Lódz, Poland.
Wojciechowski J; Institute of General and Ecological Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924, Lódz, Poland.
Wolf WM; Institute of General and Ecological Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924, Lódz, Poland.
Janecka A; Department of Biomolecular Chemistry, Medical University of Lódz, Mazowiecka 6/8, 92-215, Lódz, Poland.
Drogosz J; Department of Biomolecular Chemistry, Medical University of Lódz, Mazowiecka 6/8, 92-215, Lódz, Poland.
Dlugosz A; Department of Biomolecular Chemistry, Medical University of Lódz, Mazowiecka 6/8, 92-215, Lódz, Poland.
Krajewska U; Department of Pharmaceutical Biochemistry and Molecular Diagnostics, Faculty of Pharmacy, Medical University of Lódz, Muszynskiego 1, 90-151, Lódz, Poland.
Mirowski M; Department of Pharmaceutical Biochemistry and Molecular Diagnostics, Faculty of Pharmacy, Medical University of Lódz, Muszynskiego 1, 90-151, Lódz, Poland.
Janecki T; Institute of Organic Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924, Lódz, Poland.

Chem Biodivers ; 15(9): e1800242, 2018 Sep.

Article em En | MEDLINE | ID: mdl-29935105

Assuntos

Antineoplásicos/farmacologia; Quinolinas/síntese química; Quinolinas/farmacologia; Compostos de Tosil/síntese química; Compostos de Tosil/farmacologia; Subfamília B de Transportador de Cassetes de Ligação de ATP/antagonistas & inibidores; Subfamília B de Transportador de Cassetes de Ligação de ATP/genética; Subfamília B de Transportador de Cassetes de Ligação de ATP/metabolismo; Antineoplásicos/síntese química; Antineoplásicos/química; Linhagem Celular; Proliferação de Células/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Cristalografia por Raios X; Relação Dose-Resposta a Droga; Ensaios de Seleção de Medicamentos Antitumorais; Células Endoteliais da Veia Umbilical Humana/efeitos dos fármacos; Humanos; Modelos Moleculares; Estrutura Molecular; Quinolinas/química; Relação Estrutura-Atividade; Compostos de Tosil/química

Palavras-chave

3-methylidenequinolin-4-ones; ABCB1 transporter inhibitors; Horner-Wadsworth-Emmons olefination; cytotoxic evaluation; resonance-assisted hydrogen bond

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinolinas / Compostos de Tosil / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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