Inhibition of microRNA-16 facilitates the paclitaxel resistance by targeting IKBKB via NF-&#954;B signaling pathway in hepatocellular carcinoma.

Huang, Yingbin; Chen, Guangyu; Wang, Yang; He, Rui; Du, Jun; Jiao, Xingyuan; Tai, Qiang

Inhibition of microRNA-16 facilitates the paclitaxel resistance by targeting IKBKB via NF-κB signaling pathway in hepatocellular carcinoma.

Huang, Yingbin; Chen, Guangyu; Wang, Yang; He, Rui; Du, Jun; Jiao, Xingyuan; Tai, Qiang.

Afiliação

Huang Y; Organ Transplantation Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.
Chen G; Organ Transplantation Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.
Wang Y; Organ Transplantation Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.
He R; Organ Transplantation Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.
Du J; Department of Microbial and Biochemical Pharmacy, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Jiao X; Organ Transplantation Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China. Electronic address: jiaoxingyuan@hotmail.com.
Tai Q; Organ Transplantation Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China. Electronic address: tai2004qiang@163.com.

Biochem Biophys Res Commun ; 503(2): 1035-1041, 2018 09 05.

Article em En | MEDLINE | ID: mdl-29935185

Assuntos

Antineoplásicos Fitogênicos/farmacologia; Carcinoma Hepatocelular/tratamento farmacológico; Resistencia a Medicamentos Antineoplásicos; Quinase I-kappa B/genética; Neoplasias Hepáticas/tratamento farmacológico; MicroRNAs/genética; Paclitaxel/farmacologia; Animais; Antineoplásicos Fitogênicos/uso terapêutico; Carcinoma Hepatocelular/genética; Carcinoma Hepatocelular/metabolismo; Linhagem Celular Tumoral; Regulação para Baixo/efeitos dos fármacos; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Humanos; Quinase I-kappa B/metabolismo; Neoplasias Hepáticas/genética; Neoplasias Hepáticas/metabolismo; Masculino; Camundongos Endogâmicos BALB C; Camundongos Nus; NF-kappa B/metabolismo; Paclitaxel/uso terapêutico; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

Hepatocellular carcinoma; IKBKB; NF-κB; Paclitaxel resistance; miR-16

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Paclitaxel / Carcinoma Hepatocelular / Resistencia a Medicamentos Antineoplásicos / MicroRNAs / Quinase I-kappa B / Neoplasias Hepáticas / Antineoplásicos Fitogênicos Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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