Phthalide dimers from Angelica sinensis and their COX-2 inhibition activity.
Fitoterapia
; 129: 102-107, 2018 Sep.
Article
em En
| MEDLINE
| ID: mdl-29935258
Four new dimeric phthalides, angesinenolides C-F (1-4), along with three known ones, were isolated from the roots of Angelica sinensis. Their structures were determined by means of HRMS and NMR experiments. The structures of compounds 1 and 3 were confirmed using X-ray crystallographic data. All isolated compounds were tested for activities on the inhibition of COX-2 enzyme in vitro. Compounds 1-6 exhibited inhibitory activity against COX-2 with IC50 values ranging from 29.32⯱â¯0.07 to 137.91⯱â¯0.24⯵M.
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Base de dados:
MEDLINE
Assunto principal:
Benzofuranos
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Angelica sinensis
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Inibidores de Ciclo-Oxigenase 2
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article