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Phthalide dimers from Angelica sinensis and their COX-2 inhibition activity.
Lv, Jie-Li; Zhang, Lai-Bin; Guo, Li-Min.
Afiliação
  • Lv JL; School of Pharmacy, Xinxiang Medical University, Xinxiang 453003, PR China.
  • Zhang LB; School of Pharmacy, Xinxiang Medical University, Xinxiang 453003, PR China. Electronic address: zhanglb@xxmu.edu.cn.
  • Guo LM; School of Pharmacy, Xinxiang Medical University, Xinxiang 453003, PR China.
Fitoterapia ; 129: 102-107, 2018 Sep.
Article em En | MEDLINE | ID: mdl-29935258
Four new dimeric phthalides, angesinenolides C-F (1-4), along with three known ones, were isolated from the roots of Angelica sinensis. Their structures were determined by means of HRMS and NMR experiments. The structures of compounds 1 and 3 were confirmed using X-ray crystallographic data. All isolated compounds were tested for activities on the inhibition of COX-2 enzyme in vitro. Compounds 1-6 exhibited inhibitory activity against COX-2 with IC50 values ranging from 29.32 ±â€¯0.07 to 137.91 ±â€¯0.24 µM.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzofuranos / Angelica sinensis / Inibidores de Ciclo-Oxigenase 2 Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzofuranos / Angelica sinensis / Inibidores de Ciclo-Oxigenase 2 Idioma: En Ano de publicação: 2018 Tipo de documento: Article