Idiopathic nephrotic syndrome in South African children.
Afr Health Sci
; 17(4): 1130-1136, 2017 Dec.
Article
em En
| MEDLINE
| ID: mdl-29937885
ABSTRACT
BACKGROUND:
Different histo-pathological types and treatment response patterns of Idiopathic nephrotic syndrome (INS) have been associated with differences in ethnicity and geographical location.OBJECTIVE:
To provide an update on the steroid response and renal histo-pathological pattern in children treated for INS.METHOD:
Medical records of children with INS treated at the Charlotte Maxeke Johannesburg Academic Hospital were reviewed.RESULTS:
Mean age was 5.3 years ± 2.8. The majority (68.1%) of the 163 children were of the black racial group. The highest rate of INS was seen in the 2-6 year age group (71.2%). The black racial group had the highest rate (42/111; 37.8%) of focal segmental glomerulosclerosis (FSGS), and the white race had the highest rate (9/14; 64.3%) of minimal change disease (MCD). Ninety four (57.7%) patients were steroid sensitive (SSNS) while 69 patients (42.3%) were steroid resistant (SRNS). Minimal change disease was the most common histo-pathological type seen in SSNS (60%), while FSGS was the most common observed in patients who had SRNS (65.2%).CONCLUSION:
There appears to be a higher rate of FSGS in all the racial groups, and also a higher rate of MCD in the black race group, when compared to previous reports.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Esteroides
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Glomerulosclerose Segmentar e Focal
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Rim
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Nefrose
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Síndrome Nefrótica
Tipo de estudo:
Observational_studies
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Risk_factors_studies
Limite:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Male
País como assunto:
Africa
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article