Characterization of methanthelinium binding and function at human M<sub>1</sub>-M<sub>5</sub> muscarinic acetylcholine receptors.

Irmen, Matthias; Holze, Janine; Bödefeld, Theresa; Tränkle, Christian

Characterization of methanthelinium binding and function at human M₁-M₅ muscarinic acetylcholine receptors.

Irmen, Matthias; Holze, Janine; Bödefeld, Theresa; Tränkle, Christian.

Afiliação

Irmen M; Pharmacology and Toxicology, Institute of Pharmacy, University of Bonn, Gerhard-Domagk-Straße 3, 53121, Bonn, Germany.
Holze J; Pharmacology and Toxicology, Institute of Pharmacy, University of Bonn, Gerhard-Domagk-Straße 3, 53121, Bonn, Germany.
Bödefeld T; Pharmacology and Toxicology, Institute of Pharmacy, University of Bonn, Gerhard-Domagk-Straße 3, 53121, Bonn, Germany.
Tränkle C; Pharmacology and Toxicology, Institute of Pharmacy, University of Bonn, Gerhard-Domagk-Straße 3, 53121, Bonn, Germany. traenkle@uni-bonn.de.

Naunyn Schmiedebergs Arch Pharmacol ; 391(10): 1037-1052, 2018 10.

Article em En | MEDLINE | ID: mdl-29938305

Assuntos

Metantelina/farmacologia; Antagonistas Muscarínicos/farmacologia; Receptores Muscarínicos/metabolismo; Animais; Ligação Competitiva; Células CHO; Cricetulus; Humanos; N-Metilescopolamina/farmacologia; Ligação Proteica; Ensaio Radioligante; Receptores Muscarínicos/genética

Palavras-chave

Allosteric; Hyperhidrosis axillaris; Methanthelinium bromide; Muscarinic receptor; NMS; Orthosteric

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores Muscarínicos / Antagonistas Muscarínicos / Metantelina Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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