Physiologically based pharmacokinetic-quantitative systems toxicology and safety (PBPK-QSTS) modeling approach applied to predict the variability of amitriptyline pharmacokinetics and cardiac safety in populations and in individuals.

Tylutki, Zofia; Mendyk, Aleksander; Polak, Sebastian

Tylutki, Zofia; Mendyk, Aleksander; Polak, Sebastian.

Afiliação

Tylutki Z; Unit of Pharmacoepidemiology and Pharmacoeconomics, Department of Social Pharmacy, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9 Str., 30-688, Krakow, Poland. zofia.tylutki@doctoral.uj.edu.pl.
Mendyk A; Department of Pharmaceutical Technology and Biopharmaceutics, Jagiellonian University Medical College, Medyczna 9 St, 30-688, Krakow, Poland.
Polak S; Unit of Pharmacoepidemiology and Pharmacoeconomics, Department of Social Pharmacy, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9 Str., 30-688, Krakow, Poland.

J Pharmacokinet Pharmacodyn ; 45(5): 663-677, 2018 Oct.

Article em En | MEDLINE | ID: mdl-29943290

Assuntos

Amitriptilina/efeitos adversos; Amitriptilina/farmacocinética; Coração/efeitos dos fármacos; Adolescente; Adulto; Idoso; Arritmias Cardíacas/induzido quimicamente; Eletrofisiologia/métodos; Feminino; Frequência Cardíaca/efeitos dos fármacos; Humanos; Masculino; Pessoa de Meia-Idade; Modelos Biológicos; Farmacocinética; Medicina de Precisão/métodos; Xenobióticos/efeitos adversos; Xenobióticos/farmacologia; Adulto Jovem

Palavras-chave

Cardiac safety; Pharmacokinetic/pharmacodynamic (PK/PD) modeling; Pharmacokinetics; Physiologically based pharmacokinetic (PBPK) modeling; Toxicokinetics

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Coração / Amitriptilina Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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