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[Effect of Huazhuo Jiedu formula on HIF-1α, VEGF, and PTEN in chronic erosive gastritis patients with syndrome of accumulation of turbidity and toxicity].
Lyu, Jing-Jing; Wang, Yan-Gang; Lyu, Xue-Yan.
Afiliação
  • Lyu JJ; Hebei Medical University, Shijiazhuang 050011, China.
  • Wang YG; Hebei Medical University, Shijiazhuang 050011, China.
  • Lyu XY; Nuclear and Radiation Safety Center, Beijing 100082, China.
Zhongguo Zhong Yao Za Zhi ; 43(11): 2384-2390, 2018 Jun.
Article em Zh | MEDLINE | ID: mdl-29945395
To observe the clinical efficacy of Huazhuo Jiedu formula in treating chronic erosive gastritis (CEG) patients with syndrome of accumulation of turbidity and toxicity, explore its mechanism by observing the changes in expression levels of hypoxia inducible factor (HIF-1α), vascular endothelial growth factor (VEGF) in serum and gastric mucosa tissues after treatment, and provide theoretical basis for the clinical application of Huazhuo Jiedu formula in treating chronic erosive gastritis. All 70 patient of CEG were randomly divided into control group and treatment group, 35 cases in each group. The patients in control group received Alatan Wuwei Wan, bid, 1 bag/time; while the patients in treatment group were given with Huazhuo Jiedu formula, 1 dose/day. The course of the treatment was 6 months in both groups. The changes in clinical symptoms, gastroscopic signs, pathology and the expression levels of HIF-1α, VEGF, and phosphatase and tensin homolog deleted on chromosome ten (PTEN) in serum and gastric mucosa tissues were observed in both groups. The results showed that treatment group was better than control group in clinical efficacy, gastroscopic efficacy and pathological effect after treatment (P<0.05); the levels of HIF-1α and VEGF in serum of treatment group were lower than those in the control group after treatment (P<0.05), while the level of PTEN in serum of treatment group was higher than that in the control group after treatment (P<0.05); the levels of HIF-1α and VEGF in gastric mucosa tissues in the treatment group were lower than those in the control group after treatment, while the level of PTEN in gastric mucosa tissues in treatment group was higher than that in the control group after treatment (P<0.05), with statistically significant differences between these two groups (P<0.05). Huazhuo Jiedu formula can improve the clinical symptoms, gastroscopic signs and pathological conditions in CEG patients with syndrome of accumulation of turbidity and toxicity, and the mechanism may be associated with decreasing the expression level of HIF-1α, VEGF and increasing the expression level of PTEN.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Medicamentos de Ervas Chinesas / Fator A de Crescimento do Endotélio Vascular / PTEN Fosfo-Hidrolase / Subunidade alfa do Fator 1 Induzível por Hipóxia / Gastrite Tipo de estudo: Clinical_trials Limite: Humans Idioma: Zh Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Medicamentos de Ervas Chinesas / Fator A de Crescimento do Endotélio Vascular / PTEN Fosfo-Hidrolase / Subunidade alfa do Fator 1 Induzível por Hipóxia / Gastrite Tipo de estudo: Clinical_trials Limite: Humans Idioma: Zh Ano de publicação: 2018 Tipo de documento: Article