Non-motor effects of deep brain stimulation in dystonia: A systematic review.
Parkinsonism Relat Disord
; 55: 26-44, 2018 10.
Article
em En
| MEDLINE
| ID: mdl-29945825
ABSTRACT
INTRODUCTION:
Deep brain stimulation (DBS) has emerged as an effective treatment in medically intractable dystonia, with the globus pallidus internus (GPi) being most frequently targeted. Non-motor symptoms, including pain and psychiatric, cognitive and sleep disturbances, are increasingly recognized as important determinants of disease burden in dystonia patients. We reviewed non-motor outcomes of DBS in dystonia, focusing on GPi-DBS.METHODS:
A systematic literature search of Pubmed and Embase was performed according to the PRISMA guidelines.RESULTS:
Fifty-two studies were included. GPi-DBS reduced pain related to dystonia. No major effects on anxiety, mood, and cognition were found. In contrast to motor outcome, non-motor outcome seems more independent of the etiology of dystonia. However, the impact of potential confounders (e.g. patient factors, changes in pharmacological treatment) is unclear.CONCLUSION:
Despite the growing interest in non-motor symptoms in dystonia, DBS studies still focus primarily on motor outcome. We recommend systematic evaluation of both non-motor and motor features before and after DBS interventions to improve quality of life and management of patients with dystonia.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Transtornos Cognitivos
/
Transtornos do Humor
/
Estimulação Encefálica Profunda
/
Distonia
Tipo de estudo:
Etiology_studies
/
Guideline
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article