Probing the colorectal cancer proteome for biomarkers: Current status and perspectives.
J Proteomics
; 187: 93-105, 2018 09 15.
Article
em En
| MEDLINE
| ID: mdl-29953962
ABSTRACT
Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide. Biomarkers that can facilitate better clinical management of CRC are in high demand to improve patient outcome and to reduce mortality. In this regard, proteomic analysis holds a promising prospect in the hunt of novel biomarkers for CRC and in understanding the mechanisms underlying tumorigenesis. This review aims to provide an overview of the current progress of proteomic research, focusing on discovery and validation of diagnostic biomarkers for CRC. We will summarize the contributions of proteomic strategies to recent discoveries of protein biomarkers for CRC and also briefly discuss the potential and challenges of different proteomic approaches in biomarker discovery and translational applications.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Colorretais
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Biomarcadores Tumorais
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Proteoma
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Proteômica
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article