Hepatoprotective effect of ginsenoside Rg1 from Panax ginseng on carbon tetrachloride-induced acute liver injury by activating Nrf2 signaling pathway in mice.

Ning, Chenqing; Gao, Xiaoguang; Wang, Changyuan; Huo, Xiaokui; Liu, Zhihao; Sun, Huijun; Yang, Xiaobo; Sun, Pengyuan; Ma, Xiaodong; Meng, Qiang; Liu, Kexin

Ning, Chenqing; Gao, Xiaoguang; Wang, Changyuan; Huo, Xiaokui; Liu, Zhihao; Sun, Huijun; Yang, Xiaobo; Sun, Pengyuan; Ma, Xiaodong; Meng, Qiang; Liu, Kexin.

Afiliação

Ning C; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian 116044, China.
Gao X; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian 116044, China.
Wang C; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian 116044, China.
Huo X; Key Laboratory of Pharmacokinetics and Transport of Liaoning Province, Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian 116044, China.
Liu Z; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian 116044, China.
Sun H; Key Laboratory of Pharmacokinetics and Transport of Liaoning Province, Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian 116044, China.
Yang X; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian 116044, China.
Sun P; Key Laboratory of Pharmacokinetics and Transport of Liaoning Province, Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian 116044, China.
Ma X; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian 116044, China.
Meng Q; Key Laboratory of Pharmacokinetics and Transport of Liaoning Province, Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian 116044, China.
Liu K; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian 116044, China.

Environ Toxicol ; 33(10): 1050-1060, 2018 Oct.

Article em En | MEDLINE | ID: mdl-29964319

Assuntos

Doença Hepática Induzida por Substâncias e Drogas/patologia; Ginsenosídeos/farmacologia; Panax/química; Substâncias Protetoras/farmacologia; Transdução de Sinais/efeitos dos fármacos; Alanina Transaminase/sangue; Animais; Antioxidantes/metabolismo; Aspartato Aminotransferases/sangue; Tetracloreto de Carbono/toxicidade; Doença Hepática Induzida por Substâncias e Drogas/metabolismo; Doença Hepática Induzida por Substâncias e Drogas/prevenção & controle; Sistema Enzimático do Citocromo P-450/genética; Sistema Enzimático do Citocromo P-450/metabolismo; Citocinas/metabolismo; Ginsenosídeos/química; Ginsenosídeos/uso terapêutico; Fígado/efeitos dos fármacos; Fígado/patologia; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Fator 2 Relacionado a NF-E2/antagonistas & inibidores; Fator 2 Relacionado a NF-E2/genética; Fator 2 Relacionado a NF-E2/metabolismo; Estresse Oxidativo/efeitos dos fármacos; Panax/metabolismo; Substâncias Protetoras/uso terapêutico; Interferência de RNA; RNA Interferente Pequeno/metabolismo

Palavras-chave

acute liver injury; carbon tetrachloride (CCl4); inflammation response; nuclear factor erythroid-2-related factor 2 (Nrf2); oxidative stress

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Substâncias Protetoras / Ginsenosídeos / Doença Hepática Induzida por Substâncias e Drogas / Panax Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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