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SMYD3 promoter hypomethylation is associated with the risk of colorectal cancer.
Li, Bin; Pan, Ranran; Zhou, Cong; Dai, Jie; Mao, Yiyi; Chen, Min; Huang, Tianyi; Ying, Xiuru; Hu, Haochang; Zhao, Jun; Zhang, Wei; Duan, Shiwei.
Afiliação
  • Li B; Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, PR China.
  • Pan R; Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, PR China.
  • Zhou C; Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, PR China.
  • Dai J; Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, PR China.
  • Mao Y; Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, PR China.
  • Chen M; Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, PR China.
  • Huang T; Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, PR China.
  • Ying X; Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, PR China.
  • Hu H; Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, PR China.
  • Zhao J; Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, PR China.
  • Zhang W; Department of Preventive Medicine & The Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
  • Duan S; Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, PR China.
Future Oncol ; 14(18): 1825-1834, 2018 Aug.
Article em En | MEDLINE | ID: mdl-29969917
ABSTRACT

AIM:

SMYD3 encodes histone lysine methyltransferase. The goal of our study was to investigate the association between SMYD3 methylation and colorectal cancer (CRC). MATERIALS &

METHODS:

SMYD3 methylation was measured by quantitative methylation-specific PCR method in 117 pairs of CRC tumor and para-tumor tissues.

RESULTS:

Significantly lower SMYD3 methylation was observed in CRC tumor tissues than para-tumor tissues (p = 0.002). Further subgroup analysis by clinical features showed that significantly lower SMYD3 methylation were only observed in the CRC patients with tumors of moderately and well differentiation, positive lymph node metastasis, and stage III + IV.

CONCLUSION:

Our work reported for the first time that SMYD3 promoter hypomethylation was associated with CRC.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Regulação Neoplásica da Expressão Gênica / Histona-Lisina N-Metiltransferase / Regiões Promotoras Genéticas / Metilação de DNA Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Regulação Neoplásica da Expressão Gênica / Histona-Lisina N-Metiltransferase / Regiões Promotoras Genéticas / Metilação de DNA Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2018 Tipo de documento: Article