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Dihydroretinoic acids and their derivatives. Synthesis and biological activity.
J Med Chem ; 20(7): 918-25, 1977 Jul.
Article em En | MEDLINE | ID: mdl-299711
The syntheses of the ring and four side-chain dihydroretinoic acids and/or their esters, 3-7, are described. The syntheses of several other retinoids containing a substituted aromatic ring are also included. The biological activity of the compounds was evaluated in vivo in a chemically induced mouse skin papilloma test and in vitro in two vitamin A deficient assays. The activity observed for 1a, 1c, and 2a in the former test was partially retained in the dihydro derivatives 4b, 4c, and 6b. Similar results were found in the in vitro assays.
Assuntos
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Base de dados: MEDLINE Assunto principal: Tretinoína / Vitamina A Limite: Animals Idioma: En Ano de publicação: 1977 Tipo de documento: Article
Buscar no Google
Base de dados: MEDLINE Assunto principal: Tretinoína / Vitamina A Limite: Animals Idioma: En Ano de publicação: 1977 Tipo de documento: Article