Nitric oxide promotes cancer cell dedifferentiation by disrupting an Oct4:caveolin-1 complex: A new regulatory mechanism for cancer stem cell formation.

Maiuthed, Arnatchai; Bhummaphan, Narumol; Luanpitpong, Sudjit; Mutirangura, Apiwat; Aporntewan, Chatchawit; Meeprasert, Arthitaya; Rungrotmongkol, Thanyada; Rojanasakul, Yon; Chanvorachote, Pithi

Maiuthed, Arnatchai; Bhummaphan, Narumol; Luanpitpong, Sudjit; Mutirangura, Apiwat; Aporntewan, Chatchawit; Meeprasert, Arthitaya; Rungrotmongkol, Thanyada; Rojanasakul, Yon; Chanvorachote, Pithi.

Afiliação

Maiuthed A; From the Department of Pharmacology and Physiology.
Bhummaphan N; Cell-based Drug and Health Products Development Research Unit, Faculty of Pharmaceutical Sciences.
Luanpitpong S; Cell-based Drug and Health Products Development Research Unit, Faculty of Pharmaceutical Sciences.
Mutirangura A; the Inter-Department Program of Biomedical Sciences, Faculty of Graduate School, Chulalongkorn University, Bangkok 10330, Thailand.
Aporntewan C; the Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700 Thailand, and.
Meeprasert A; the Center of Excellence in Molecular Genetics of Cancer and Human Diseases, Department of Anatomy, Faculty of Medicine, and.
Rungrotmongkol T; the Department of Mathematics and Computer Science.
Rojanasakul Y; Structural and Computational Biology Research Group, and Department of Biochemistry, Faculty of Science.
Chanvorachote P; Structural and Computational Biology Research Group, and Department of Biochemistry, Faculty of Science.

J Biol Chem ; 293(35): 13534-13552, 2018 08 31.

Article em En | MEDLINE | ID: mdl-29986880

Assuntos

Caveolina 1/metabolismo; Desdiferenciação Celular; Neoplasias Pulmonares/metabolismo; Células-Tronco Neoplásicas/metabolismo; Óxido Nítrico/metabolismo; Fator 3 de Transcrição de Octâmero/metabolismo; Caveolina 1/genética; Linhagem Celular Tumoral; Regulação Neoplásica da Expressão Gênica; Humanos; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/patologia; Modelos Moleculares; Mutação; Células-Tronco Neoplásicas/citologia; Células-Tronco Neoplásicas/patologia; Fator 3 de Transcrição de Octâmero/genética; Mapas de Interação de Proteínas; Proteólise; Transcriptoma

Palavras-chave

GSK3ß; OCT4; cancer biology; cancer stem cells; caveolin; cell signaling; differentiation; lung cancer; nitric oxide, caveolin-1; proteasome; protein degradation; proteinprotein interaction; regulation

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco Neoplásicas / Caveolina 1 / Fator 3 de Transcrição de Octâmero / Desdiferenciação Celular / Neoplasias Pulmonares / Óxido Nítrico Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google