Formal [7 + 2] Cycloaddition of Arynes with N-Vinyl-α,ß-Unsaturated Nitrones: Synthesis of Benzoxazonines and Their N-O Bond Cleavage.
Org Lett
; 20(15): 4571-4574, 2018 08 03.
Article
em En
| MEDLINE
| ID: mdl-30003790
ABSTRACT
Various benzoxazonines were synthesized through a formal [7 + 2] cycloaddition of arynes with N-vinyl-α,ß-unsaturated nitrones under mild conditions. Controllable N-O bond cleavage of benzoxazonines afforded polysubstituted pyrrole-tethered benzopyrans and acyclic ketone-substituted phenols in moderate to good yields. Further transformations provided a facile approach to access useful building blocks with specific stereoselectivity.
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MEDLINE
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En
Ano de publicação:
2018
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Article