Dimethyl fumarate-induced IL-17low IFN-γlow IL-4+ Th cells protect mice from severe encephalomyelitis.
Eur J Immunol
; 48(9): 1588-1591, 2018 09.
Article
em En
| MEDLINE
| ID: mdl-30007005
ABSTRACT
Dimethyl fumarate (DMF) promotes an IL-17Alow IFN-γlow IL-4+ CD4+ T cell phenotype. Adoptive transfer of in vitro DMF-treated myelin peptide-reactive IL-17Alow IFN-γlow IL-4+ CD4+ T cells prior to immunization for EAE reduces the severity of encephalomyelitis. This beneficial effect of transferred DMF-treated CD4+ T cells requires an early in vivo recall.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T CD4-Positivos
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Interleucina-4
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Interferon gama
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Encefalomielite Autoimune Experimental
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Células Th17
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Fumarato de Dimetilo
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Imunossupressores
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article