Dimethyl fumarate-induced IL-17low IFN-Î³low IL-4+ Th cells protect mice from severe encephalomyelitis.

Brück, Jürgen; Glocova, Ivana; Geisel, Julia; Kellerer, Christina; Röcken, Martin; Ghoreschi, Kamran

Dimethyl fumarate-induced IL-17^low IFN-Î³^low IL-4⁺ Th cells protect mice from severe encephalomyelitis.

Brück, Jürgen; Glocova, Ivana; Geisel, Julia; Kellerer, Christina; Röcken, Martin; Ghoreschi, Kamran.

Afiliação

Brück J; Department of Dermatology, University Medical Center, Eberhard Karls University Tübingen, Tübingen, Germany.
Glocova I; Department of Dermatology, University Medical Center, Eberhard Karls University Tübingen, Tübingen, Germany.
Geisel J; Department of Dermatology, University Medical Center, Eberhard Karls University Tübingen, Tübingen, Germany.
Kellerer C; Department of Dermatology, University Medical Center, Eberhard Karls University Tübingen, Tübingen, Germany.
Röcken M; Department of Dermatology, University Medical Center, Eberhard Karls University Tübingen, Tübingen, Germany.
Ghoreschi K; Department of Dermatology, University Medical Center, Eberhard Karls University Tübingen, Tübingen, Germany.

Eur J Immunol ; 48(9): 1588-1591, 2018 09.

Article em En | MEDLINE | ID: mdl-30007005

ABSTRACT

ABSTRACT

Dimethyl fumarate (DMF) promotes an IL-17Alow IFN-Î³low IL-4+ CD4+ T cell phenotype. Adoptive transfer of in vitro DMF-treated myelin peptide-reactive IL-17Alow IFN-Î³low IL-4+ CD4+ T cells prior to immunization for EAE reduces the severity of encephalomyelitis. This beneficial effect of transferred DMF-treated CD4+ T cells requires an early in vivo recall.

Assuntos

Linfócitos T CD4-Positivos/imunologia; Fumarato de Dimetilo/farmacologia; Encefalomielite Autoimune Experimental/imunologia; Encefalomielite Autoimune Experimental/prevenção & controle; Imunossupressores/farmacologia; Interferon gama/imunologia; Interleucina-4/imunologia; Células Th17/imunologia; Transferência Adotiva; Animais; Linfócitos T CD4-Positivos/transplante; Interferon gama/biossíntese; Interleucina-10/biossíntese; Interleucina-10/imunologia; Interleucina-17/biossíntese; Interleucina-17/imunologia; Interleucina-4/biossíntese; Camundongos; Células Th1/imunologia; Células Th2/imunologia

Palavras-chave

Dimethyl fumarate; EAE; Immunotherapy; T cell vaccine; Th17 cells

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos T CD4-Positivos / Interleucina-4 / Interferon gama / Encefalomielite Autoimune Experimental / Células Th17 / Fumarato de Dimetilo / Imunossupressores Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google