[Thrombotic microangiopathy/haemolytic uraemic syndrome. Histopathology update]. / Microangiopatía trombótica/síndrome hemolítico urémico. Actualización de sus características histopatológicas.
Rev Esp Patol
; 51(3): 170-177, 2018.
Article
em Es
| MEDLINE
| ID: mdl-30012310
Thrombotic microangiopathy (TMA) encompasses different entities known as haemolytic uraemic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP). The histopathological characteristics have remained constant since the initial description and consist in glomerular-type affectation with the presence of double contours, mesangiolysis and microthrombi. It is generally accepted that the vascular damage is related to the prognosis. Ultrastructure, together with conventional histology, shows notable changes in both capillaries and endothelial cells. A comprehensive histopathological study of the renal biopsy, using electronmicroscopy, is useful in the confirmation of a clinical suspicion and demonstrates the pathogenetic mechanisms in the microcirculatory damage. The close resemblance between the ultrastructural appearance and that seen with the light microscope of TMA and transplant glomerulopathy (TG) is precisely what suggests that both entities are subject to the same etiopathogenetic mechanism in which the endothelial cell is targeted. Recent advances in the pathology of atypical HUS, its relation with complement system and the discovery of specific therapeutic targets, has rekindled an interest in the study of TMA and the importance of renal biopsy.
Palavras-chave
Acute renal insufficiency (ARI); Acute tubular necrosis (ATN); Atypical hemolytic uremic syndrome (aHUS); Electronmicroscopy (EM); Glomerulopatía trasplante (GPTR); Haemolytic uremic syndrome (HUS); Insuficiencia renal aguda (IRA); Microangiopatía trombótica (MAT); Microscopio electrónico (ME); Necrosis tubular aguda (NTA); Púrpura trombótica trombocitopénica (PTT); Síndrome hemolítico urémico (SHU); Síndrome hemolítico urémico atípico (SHUa); Thrombotic microangiopathy (TMA); Thrombotic thrombocytopenic purpura (TTP); Transplant glomerulopathy (TG)
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Microangiopatias Trombóticas
/
Síndrome Hemolítico-Urêmica Atípica
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
Es
Ano de publicação:
2018
Tipo de documento:
Article