In Vitro Antiviral Activity of Cabotegravir against HIV-2.
Antimicrob Agents Chemother
; 62(10)2018 10.
Article
em En
| MEDLINE
| ID: mdl-30012774
ABSTRACT
We examined the antiviral activity of the integrase inhibitor (INI) cabotegravir against HIV-2 isolates from INI-naive individuals. HIV-2 was sensitive to cabotegravir in single-cycle and spreading-infection assays, with 50% effective concentrations (EC50s) in the low to subnanomolar range; comparable results were obtained for HIV-1 in both assay formats. Our findings suggest that cabotegravir should be evaluated in clinical trials as a potential option for antiretroviral therapy and preexposure prophylaxis in HIV-2-prevalent settings.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Piridonas
/
HIV-2
/
Fármacos Anti-HIV
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article