Anti-glycation, Carbonyl Trapping and Anti-inflammatory Activities of Chrysin Derivatives.
Molecules
; 23(7)2018 07 17.
Article
em En
| MEDLINE
| ID: mdl-30018253
ABSTRACT
The aim of this study was searching anti-glycation, carbonyl trapping and anti-inflammatory activities of chrysin derivatives. The inhibitory effect of chrysin on advanced glycation end-products (AGEs) was investigated by trapping methylglyoxal (MGO), and MGO-conjugated adducts of chrysin were analyzed using LC-MS/MS. The mono- or di-MGO-conjugated adducts of chrysin were present at 63.86 and 29.69% upon 48 h of incubation at a chrysinMGO ratio of 110. The MGO adducted positions on chrysin were at carbon 6 or 6 & 8 in the A ring by classic aldol condensation. To provide applicable knowledge for developing chrysin derivatives as AGE inhibitors, we synthesized several O-alkyl or ester derivatives of chrysin and compared their AGE formation inhibitory, anti-inflammatory, and water solubility characteristics. The results showed that 5,7-di-O-acetylchrysin possessed higher AGE inhibitory and water solubility qualities than original chrysin, and retained the anti-inflammation activity. These results suggested that 5,7-di-O-acetylchrysin could be a potent functional food ingredient as an AGE inhibitor and anti-inflammatory agent, and promotes the development of the use of chrysin in functional foods.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Flavonoides
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Produtos Finais de Glicação Avançada
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Anti-Inflamatórios
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article