5-hydroxymethylfurfural- and fluorescein-fused fluorescence probe of mast cells (RBL-2H3): Synthesis, photophysical properties, and bioimaging.
Chem Biol Drug Des
; 92(6): 1963-1971, 2018 12.
Article
em En
| MEDLINE
| ID: mdl-30022592
ABSTRACT
A fluorescent probe (Fluo-HMF) was developed via introduction of a furfural moiety into the fluorescein molecular skeleton, aiming at specially labeling cell membrane of mast cells. To illustrate its specificity, we designed and synthesized a series of fluorescent compounds based on fluorescein molecular skeleton. The fluorescent properties of Fluo-HMF were investigated, which were in accordance with theoretical calculations. Compared with other fluorescein derivatives, Fluo-HMF could specially label RBL-2H3 cells. The results suggested that Fluo-HMF could be used as a fluorescent probe for bioimaging on some related research of allergic mechanism.
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Base de dados:
MEDLINE
Assunto principal:
Fluoresceína
/
Corantes Fluorescentes
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Furaldeído
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Microscopia de Fluorescência
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article