Skin resident memory CD8<sup>+</sup> T cells are phenotypically and functionally distinct from circulating populations and lack immediate cytotoxic function.

Seidel, J A; Vukmanovic-Stejic, M; Muller-Durovic, B; Patel, N; Fuentes-Duculan, J; Henson, S M; Krueger, J G; Rustin, M H A; Nestle, F O; Lacy, K E; Akbar, A N

Skin resident memory CD8⁺ T cells are phenotypically and functionally distinct from circulating populations and lack immediate cytotoxic function.

Seidel, J A; Vukmanovic-Stejic, M; Muller-Durovic, B; Patel, N; Fuentes-Duculan, J; Henson, S M; Krueger, J G; Rustin, M H A; Nestle, F O; Lacy, K E; Akbar, A N.

Afiliação

Seidel JA; Division of Infection and Immunity, University College London, UK.
Vukmanovic-Stejic M; Division of Infection and Immunity, University College London, UK.
Muller-Durovic B; Division of Infection and Immunity, University College London, UK.
Patel N; Department of Biomedicine, University of Basel, Basel, Switzerland.
Fuentes-Duculan J; Division of Infection and Immunity, University College London, UK.
Henson SM; Laboratory for Investigative Dermatology, The Rockefeller University, New York, USA.
Krueger JG; Division of Infection and Immunity, University College London, UK.
Rustin MHA; Laboratory for Investigative Dermatology, The Rockefeller University, New York, USA.
Nestle FO; Department of Dermatology, The Royal Free Hospital, London, UK.
Lacy KE; NIHR Biomedical Research Centre, Cutaneous Medicine and Immunotherapy, St John's Institute of Dermatology, Division of Genetics and Molecular Medicine, Guy's Hospital, King's College London, London, UK.
Akbar AN; NIHR Biomedical Research Centre, Cutaneous Medicine and Immunotherapy, St John's Institute of Dermatology, Division of Genetics and Molecular Medicine, Guy's Hospital, King's College London, London, UK.

Clin Exp Immunol ; 194(1): 79-92, 2018 10.

Article em En | MEDLINE | ID: mdl-30030847

Assuntos

Memória Imunológica/imunologia; Pele/citologia; Pele/imunologia; Linfócitos T Citotóxicos/imunologia; Adulto; Idoso; Idoso de 80 Anos ou mais; Antígenos CD/metabolismo; Antígenos de Diferenciação de Linfócitos T/metabolismo; Antígenos CD28/imunologia; Antígenos CD57/metabolismo; Células Cultivadas; Feminino; Granzimas/metabolismo; Humanos; Interleucina-15/imunologia; Interleucina-2/imunologia; Lectinas Tipo C/metabolismo; Antígenos Comuns de Leucócito/metabolismo; Masculino; Pessoa de Meia-Idade; Perforina/metabolismo; Receptores Imunológicos; Transativadores/metabolismo; Membro 7 da Superfamília de Receptores de Fatores de Necrose Tumoral/metabolismo; Fator de Necrose Tumoral alfa/imunologia; Adulto Jovem

Palavras-chave

T cells; cytotoxicity; regulation; skin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pele / Linfócitos T Citotóxicos / Memória Imunológica Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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