Teriflunomide Modulates Vascular Permeability and Microglial Activation after Experimental Traumatic Brain Injury.

Prabhakara, Karthik S; Kota, Daniel J; Jones, Gregory H; Srivastava, Amit K; Cox, Charles S; Olson, Scott D

Prabhakara, Karthik S; Kota, Daniel J; Jones, Gregory H; Srivastava, Amit K; Cox, Charles S; Olson, Scott D.

Afiliação

Prabhakara KS; Program in Children's Regenerative Medicine, Department of Pediatric Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Kota DJ; Emory Personalized Immunotherapy Core Labs, Emory University, School of Medicine, Atlanta, GA 30322, USA.
Jones GH; Program in Children's Regenerative Medicine, Department of Pediatric Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Srivastava AK; Program in Children's Regenerative Medicine, Department of Pediatric Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Cox CS; Program in Children's Regenerative Medicine, Department of Pediatric Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Olson SD; Program in Children's Regenerative Medicine, Department of Pediatric Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA. Electronic address: scott.d.olson@uth.tmc.edu.

Mol Ther ; 26(9): 2152-2162, 2018 09 05.

Article em En | MEDLINE | ID: mdl-30037655

Assuntos

Lesões Encefálicas Traumáticas/tratamento farmacológico; Lesões Encefálicas Traumáticas/metabolismo; Permeabilidade Capilar/efeitos dos fármacos; Crotonatos/uso terapêutico; Microglia/efeitos dos fármacos; Microglia/metabolismo; Toluidinas/uso terapêutico; Animais; Barreira Hematoencefálica/efeitos dos fármacos; Barreira Hematoencefálica/metabolismo; Modelos Animais de Doenças; Hidroxibutiratos; Imuno-Histoquímica; Inflamação/tratamento farmacológico; Inflamação/metabolismo; Masculino; Neurogênese/efeitos dos fármacos; Nitrilas; Ratos; Ratos Sprague-Dawley; Tálamo/efeitos dos fármacos; Tálamo/metabolismo

Palavras-chave

blood-brain barrier; brain trauma; microglia; neuroinflammation; preclinical; teriflunomide

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Toluidinas / Permeabilidade Capilar / Crotonatos / Microglia / Lesões Encefálicas Traumáticas Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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