The inactivation of herpes simplex virus by some Solanaceae glycoalkaloids.
Antiviral Res
; 5(6): 335-43, 1985 Dec.
Article
em En
| MEDLINE
| ID: mdl-3004327
ABSTRACT
The infectivity of herpes simplex virus Type I in tissue culture was inhibited by prior incubation with aqueous suspensions of glycoalkaloids in order of activity alpha-chaconine greater than alpha-tomatine greater than alpha-solasonine but not by the corresponding aglycones, solanidine, tomatidine and solasodine. However, inhibition was not only dependent on the presence of a sugar moiety since the glycone alpha-solanine was inactive under the conditions used. The glycones, but not the aglycones, showed cytopathic effects on cellular membranes of Vero cells and erythrocytes; therefore, it is suggested that inactivation of virus results from insertion of the glycones into the viral envelope.
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Base de dados:
MEDLINE
Assunto principal:
Alcaloides de Solanáceas
/
Simplexvirus
Limite:
Animals
Idioma:
En
Ano de publicação:
1985
Tipo de documento:
Article