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Secondary carbamate linker can facilitate the sustained release of dopamine from brain-targeted prodrug.
Thiele, Nikki A; Kärkkäinen, Jussi; Sloan, Kenneth B; Rautio, Jarkko; Huttunen, Kristiina M.
Afiliação
  • Thiele NA; Department of Medicinal Chemistry, University of Florida, Gainesville, FL 32610, USA.
  • Kärkkäinen J; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland.
  • Sloan KB; Department of Medicinal Chemistry, University of Florida, Gainesville, FL 32610, USA.
  • Rautio J; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland.
  • Huttunen KM; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland. Electronic address: kristiina.huttunen@uef.fi.
Bioorg Med Chem Lett ; 28(17): 2856-2860, 2018 09 15.
Article em En | MEDLINE | ID: mdl-30055889
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carbamatos / Pró-Fármacos / Dopamina / Levodopa / Transportador 1 de Aminoácidos Neutros Grandes Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carbamatos / Pró-Fármacos / Dopamina / Levodopa / Transportador 1 de Aminoácidos Neutros Grandes Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article