Apolipoprotein E Deficiency Increases Remnant Lipoproteins and Accelerates Progressive Atherosclerosis, But Not Xanthoma Formation, in Gene-Modified Minipigs.

Shim, Jeong; Poulsen, Christian Bo; Hagensen, Mette K; Larsen, Torben; Heegaard, Peter M H; Christoffersen, Christina; Bolund, Lars; Schmidt, Mette; Liu, Ying; Li, Juan; Li, Rong; Callesen, Henrik; Bentzon, Jacob F; Sørensen, Charlotte B

Apolipoprotein E Deficiency Increases Remnant Lipoproteins and Accelerates Progressive Atherosclerosis, But Not Xanthoma Formation, in Gene-Modified Minipigs.

Shim, Jeong; Poulsen, Christian Bo; Hagensen, Mette K; Larsen, Torben; Heegaard, Peter M H; Christoffersen, Christina; Bolund, Lars; Schmidt, Mette; Liu, Ying; Li, Juan; Li, Rong; Callesen, Henrik; Bentzon, Jacob F; Sørensen, Charlotte B.

Afiliação

Shim J; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Poulsen CB; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
Hagensen MK; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Larsen T; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
Heegaard PMH; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Christoffersen C; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
Bolund L; Department of Animal Science, Aarhus University, Aarhus, Denmark.
Schmidt M; National Veterinary Institute, Technical University of Denmark, Lyngby, Denmark.
Liu Y; Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark.
Li J; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Li R; Section for Veterinary Reproduction and Obstetrics, Department of Veterinary Clinical Sciences, University of Copenhagen, Copenhagen, Denmark.
Callesen H; Department of Animal Science, Aarhus University, Aarhus, Denmark.
Bentzon JF; Department of Animal Science, Aarhus University, Aarhus, Denmark.
Sørensen CB; Department of Animal Science, Aarhus University, Aarhus, Denmark.

JACC Basic Transl Sci ; 2(5): 591-600, 2017 Oct.

Article em En | MEDLINE | ID: mdl-30062172

Palavras-chave

APOB, apolipoprotein B; APOE, apolipoprotein E; HFHC, high-fat high-cholesterol; IDL, intermediate-density lipoprotein; LAD, left anterior descending (coronary artery); LDL, low-density lipoprotein; LDLR, low-density lipoprotein receptor; LF, low-fat; Neo, neomycin; SMC, smooth muscle cell; VLDL, very-low-density lipoprotein; apolipoprotein E; atherosclerosis; cDNA, complementary DNA; pig; rAAV, recombinant adeno-associated virus; remnant cholesterol dysbetalipoproteinemia

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2017 Tipo de documento: Article