Multiple pesticide analysis in hair samples of pregnant French women: Results from the ELFE national birth cohort.
Environ Int
; 120: 43-53, 2018 11.
Article
em En
| MEDLINE
| ID: mdl-30064054
ABSTRACT
BACKGROUND:
A growing body of evidence suggests that prenatal exposure to pesticides might impair fetal development. Nonetheless, knowledge about pesticide exposure of pregnant women, especially in Europe, is largely restricted to a limited panel of molecules.AIM:
To characterize the concentration of 140 pesticides and metabolites in hair strands from women in the ELFE French nationwide birth cohort.METHODS:
Among cohort members who gave birth in northeastern and southwestern France in 2011, we selected those with a sufficient available mass of hair (nâ¯=â¯311). Bundles of hair 9â¯cm long were collected at delivery. We screened 111 pesticides and 29 metabolites, including 112 selected a priori based on their reported usage or detection in the French environment. The bundles of hair from 47 women were split into three segments to explore the intraindividual variability of the exposure. Intraclass correlation coefficients (ICCs) were computed for the chemicals with a detection frequency >70%.RESULTS:
We detected a median of 43 chemicals per woman (IQR 38-47). Overall, 122 chemicals (>20 chemical families) were detected at least once, including 28 chemicals detected in 70-100% of hair samples. The highest median concentrations were observed for permethrin (median 37.9â¯pg/mg of hair), p-nitrophenol (13.2â¯pg/mg), and pentachlorophenol (10.0â¯pg/mg). The ICCs for the 28 chemicals studied ranged from 0.59 to 0.94.CONCLUSION:
Pregnant women are exposed to multiple pesticides simultaneously from various chemical families, including chemicals suspected to be reproductive toxicants or endocrine disruptors. The ICCs suggest that the intraindividual variability of pesticide concentrations in hair is lower than its interindividual variability.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Praguicidas
/
Gravidez
/
Exposição Materna
/
Poluentes Ambientais
/
Cabelo
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article