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Discovery of 3-Benzyl-1-( trans-4-((5-cyanopyridin-2-yl)amino)cyclohexyl)-1-arylurea Derivatives as Novel and Selective Cyclin-Dependent Kinase 12 (CDK12) Inhibitors.
Ito, Masahiro; Tanaka, Toshio; Toita, Akinori; Uchiyama, Noriko; Kokubo, Hironori; Morishita, Nao; Klein, Michael G; Zou, Hua; Murakami, Morio; Kondo, Mitsuyo; Sameshima, Tomoya; Araki, Shinsuke; Endo, Satoshi; Kawamoto, Tomohiro; Morin, Gregg B; Aparicio, Samuel A; Nakanishi, Atsushi; Maezaki, Hironobu; Imaeda, Yasuhiro.
Afiliação
  • Ito M; Pharmaceutical Research Division , Takeda Pharmaceutical Company Limited , 26-1, Muraoka-Higashi 2-chome , Fujisawa , Kanagawa 251-8555 , Japan.
  • Tanaka T; Pharmaceutical Research Division , Takeda Pharmaceutical Company Limited , 26-1, Muraoka-Higashi 2-chome , Fujisawa , Kanagawa 251-8555 , Japan.
  • Toita A; Pharmaceutical Research Division , Takeda Pharmaceutical Company Limited , 26-1, Muraoka-Higashi 2-chome , Fujisawa , Kanagawa 251-8555 , Japan.
  • Uchiyama N; Pharmaceutical Research Division , Takeda Pharmaceutical Company Limited , 26-1, Muraoka-Higashi 2-chome , Fujisawa , Kanagawa 251-8555 , Japan.
  • Kokubo H; Pharmaceutical Research Division , Takeda Pharmaceutical Company Limited , 26-1, Muraoka-Higashi 2-chome , Fujisawa , Kanagawa 251-8555 , Japan.
  • Morishita N; Pharmaceutical Research Division , Takeda Pharmaceutical Company Limited , 26-1, Muraoka-Higashi 2-chome , Fujisawa , Kanagawa 251-8555 , Japan.
  • Klein MG; Department of Structural Biology , Takeda California Inc. , 10410 Science Center Drive , San Diego , California 92121 , United States.
  • Zou H; Department of Structural Biology , Takeda California Inc. , 10410 Science Center Drive , San Diego , California 92121 , United States.
  • Murakami M; Pharmaceutical Research Division , Takeda Pharmaceutical Company Limited , 26-1, Muraoka-Higashi 2-chome , Fujisawa , Kanagawa 251-8555 , Japan.
  • Kondo M; Pharmaceutical Research Division , Takeda Pharmaceutical Company Limited , 26-1, Muraoka-Higashi 2-chome , Fujisawa , Kanagawa 251-8555 , Japan.
  • Sameshima T; Pharmaceutical Research Division , Takeda Pharmaceutical Company Limited , 26-1, Muraoka-Higashi 2-chome , Fujisawa , Kanagawa 251-8555 , Japan.
  • Araki S; Pharmaceutical Research Division , Takeda Pharmaceutical Company Limited , 26-1, Muraoka-Higashi 2-chome , Fujisawa , Kanagawa 251-8555 , Japan.
  • Endo S; Pharmaceutical Research Division , Takeda Pharmaceutical Company Limited , 26-1, Muraoka-Higashi 2-chome , Fujisawa , Kanagawa 251-8555 , Japan.
  • Kawamoto T; Pharmaceutical Research Division , Takeda Pharmaceutical Company Limited , 26-1, Muraoka-Higashi 2-chome , Fujisawa , Kanagawa 251-8555 , Japan.
  • Morin GB; Genome Sciences Centre , British Columbia Cancer Agency , 675 West 10th Avenue , Vancouver , British Columbia V5Z 1L3 , Canada.
  • Aparicio SA; Department of Medical Genetics , University of British Columbia , Vancouver , British Columbia V6H 3N1 , Canada.
  • Nakanishi A; Department of Molecular Oncology , British Columbia Cancer Agency , 675 West 10th Avenue , Vancouver , British Columbia V5Z 1L3 , Canada.
  • Maezaki H; Pharmaceutical Research Division , Takeda Pharmaceutical Company Limited , 26-1, Muraoka-Higashi 2-chome , Fujisawa , Kanagawa 251-8555 , Japan.
  • Imaeda Y; Pharmaceutical Research Division , Takeda Pharmaceutical Company Limited , 26-1, Muraoka-Higashi 2-chome , Fujisawa , Kanagawa 251-8555 , Japan.
J Med Chem ; 61(17): 7710-7728, 2018 09 13.
Article em En | MEDLINE | ID: mdl-30067358
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Sobrevivência Celular / Quinases Ciclina-Dependentes / Inibidores Enzimáticos / Descoberta de Drogas Limite: Female / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Sobrevivência Celular / Quinases Ciclina-Dependentes / Inibidores Enzimáticos / Descoberta de Drogas Limite: Female / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article