Inhibition of cytokine-mediated JNK signalling by purinergic P2Y<sub>11</sub> receptors, a novel protective mechanism in endothelial cells.

Ng, Pei Y; McIntosh, Kathryn A; Hargrave, Gillian; Ho, Ka H; Paul, Andrew; Plevin, Robin

Inhibition of cytokine-mediated JNK signalling by purinergic P2Y₁₁ receptors, a novel protective mechanism in endothelial cells.

Ng, Pei Y; McIntosh, Kathryn A; Hargrave, Gillian; Ho, Ka H; Paul, Andrew; Plevin, Robin.

Afiliação

Ng PY; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, Scotland, UK.
McIntosh KA; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, Scotland, UK. Electronic address: kathryn.a.mcintosh@strath.ac.uk.
Hargrave G; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, Scotland, UK.
Ho KH; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, Scotland, UK.
Paul A; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, Scotland, UK.
Plevin R; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, Scotland, UK.

Cell Signal ; 51: 59-71, 2018 11.

Article em En | MEDLINE | ID: mdl-30076967

Assuntos

Vasos Coronários; Células Endoteliais/metabolismo; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Antagonistas do Receptor Purinérgico P2Y/farmacologia; Receptores Purinérgicos P2/metabolismo; Trifosfato de Adenosina/metabolismo; Células Cultivadas; Vasos Coronários/citologia; Vasos Coronários/metabolismo; Células Endoteliais/citologia; Células Endoteliais da Veia Umbilical Humana; Humanos; Interleucina-1beta/metabolismo; Receptores Purinérgicos P1/metabolismo; Receptores Purinérgicos P2Y1/metabolismo; Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

C-Jun N-terminal kinase; G-protein coupled receptors; H-89 (PubChem CID: 449241); Inflammation; Interleukin-1ß; MRS2179 (PubChem CID: 24867852); NF340 (PubChem CID: 73755007); Purinergic receptors; YM-254890 (PubChem CID: 9919454); ZM241385 (PubChem CID: 176407)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores Purinérgicos P2 / Vasos Coronários / Sistema de Sinalização das MAP Quinases / Células Endoteliais / Antagonistas do Receptor Purinérgico P2Y Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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