Pharmacokinetics of Phosphatidylethanol 16:0/20:4 in Human Blood After Alcohol Intake.
Alcohol Clin Exp Res
; 42(11): 2094-2099, 2018 11.
Article
em En
| MEDLINE
| ID: mdl-30091144
ABSTRACT
BACKGROUND:
The purpose of this study was to characterize the pharmacokinetics of the phosphatidylethanol (PEth) 160/204 homolog in uncoagulated human blood samples taken from 18 participants in a clinical laboratory setting after consumption of 2 standard doses of ethanol (EtOH).METHODS:
Male and female participants received either 0.4 or 0.8 g/kg oral doses of EtOH during a 15-minute period. Blood samples were collected before and throughout 6 hours immediately after alcohol administration and then again at days 2, 4, 7, 11, and 14 of the follow-up period. PEth 160/204 levels were quantified by high-performance liquid chromatography with tandem mass spectrometry detection.RESULTS:
(i) The increase in PEth 160/204 from baseline to maximum concentration was less than that of PEth 160/181 or PEth 160/182 homologs during the 6-hour period after EtOH administration; (ii) the mean half-life of PEth 160/204 was 2.1 ± 3 (SD) days, which was shorter than the mean half-life of either PEth 160/181 or PEth 160/182, 7.6 ± 3 (SD) or 6.8 ± 4 (SD) days, respectively.CONCLUSIONS:
The pharmacokinetics of PEth 160/204 in whole blood samples is detectable after alcohol consumption and differs in amount synthesized and rate of elimination versus PEth 160/181 and 160/182. Measuring the concentrations of these 3 homologs has the potential to provide more information about the amount and time frame of alcohol consumption than any one alone.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Depressores do Sistema Nervoso Central
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Glicerofosfolipídeos
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Etanol
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article