Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers.
Cell
; 174(4): 780-784, 2018 08 09.
Article
em En
| MEDLINE
| ID: mdl-30096309
Krebs cycle intermediates traditionally link to oxidative phosphorylation whilst also making key cell components. It is now clear that some of these metabolites also act as signals. Succinate plays an important role in inflammatory, hypoxic, and metabolic signaling, while itaconate (from another Krebs cycle intermediate, cis-aconitate) has an anti-inflammatory role.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Succinatos
/
Ciclo do Ácido Cítrico
/
Ácido Succínico
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article