Is Severe and Long-lasting Linezolid-induced Optic Neuropathy Reversible?
Intern Med
; 57(24): 3611-3613, 2018 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-30101940
ABSTRACT
Linezolid is a useful drug for treating drug-resistant tuberculosis. However, the associated toxicities, especially optic neuritis, are a major obstacle for its long-term use. We recently experienced a case of severe optic and peripheral neuropathy during the treatment of multidrug-resistant tuberculosis. The treatment continued for 12 months despite severe optic and peripheral neuropathy. At eight months after the discontinuation of the drug, the optic neuropathy recovered, but the peripheral neuropathy did not. Considering the grave prognosis of drug-resistant tuberculosis, the continuation of linezolid despite neurotoxicity under close observation may be a suitable option.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Doenças do Nervo Óptico
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Tuberculose Resistente a Múltiplos Medicamentos
/
Linezolida
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Antituberculosos
Tipo de estudo:
Prognostic_studies
Limite:
Adult
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Female
/
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article