Chromatin-dependent allosteric regulation of DNMT3A activity by MeCP2.

Rajavelu, Arumugam; Lungu, Cristiana; Emperle, Max; Dukatz, Michael; Bröhm, Alexander; Broche, Julian; Hanelt, Ines; Parsa, Edris; Schiffers, Sarah; Karnik, Rahul; Meissner, Alexander; Carell, Thomas; Rathert, Philipp; Jurkowska, Renata Z; Jeltsch, Albert

Rajavelu, Arumugam; Lungu, Cristiana; Emperle, Max; Dukatz, Michael; Bröhm, Alexander; Broche, Julian; Hanelt, Ines; Parsa, Edris; Schiffers, Sarah; Karnik, Rahul; Meissner, Alexander; Carell, Thomas; Rathert, Philipp; Jurkowska, Renata Z; Jeltsch, Albert.

Afiliação

Rajavelu A; Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, Faculty of Chemistry, University Stuttgart, Allmandring 31, 70569 Stuttgart, Germany.
Lungu C; Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, Faculty of Chemistry, University Stuttgart, Allmandring 31, 70569 Stuttgart, Germany.
Emperle M; Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, Faculty of Chemistry, University Stuttgart, Allmandring 31, 70569 Stuttgart, Germany.
Dukatz M; Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, Faculty of Chemistry, University Stuttgart, Allmandring 31, 70569 Stuttgart, Germany.
Bröhm A; Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, Faculty of Chemistry, University Stuttgart, Allmandring 31, 70569 Stuttgart, Germany.
Broche J; Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, Faculty of Chemistry, University Stuttgart, Allmandring 31, 70569 Stuttgart, Germany.
Hanelt I; Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, Faculty of Chemistry, University Stuttgart, Allmandring 31, 70569 Stuttgart, Germany.
Parsa E; Center for Integrated Protein Science (CiPSM) at the Department of Chemistry, Ludwig-Maximilians-University, Butenandtstr. 5-13, 81377 Munich, Germany.
Schiffers S; Center for Integrated Protein Science (CiPSM) at the Department of Chemistry, Ludwig-Maximilians-University, Butenandtstr. 5-13, 81377 Munich, Germany.
Karnik R; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
Meissner A; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Carell T; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
Rathert P; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Jurkowska RZ; Center for Integrated Protein Science (CiPSM) at the Department of Chemistry, Ludwig-Maximilians-University, Butenandtstr. 5-13, 81377 Munich, Germany.
Jeltsch A; Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, Faculty of Chemistry, University Stuttgart, Allmandring 31, 70569 Stuttgart, Germany.

Nucleic Acids Res ; 46(17): 9044-9056, 2018 09 28.

Article em En | MEDLINE | ID: mdl-30102379

Assuntos

Cromatina/metabolismo; DNA (Citosina-5-)-Metiltransferases/genética; DNA/química; Epigênese Genética; Histonas/genética; Proteína 2 de Ligação a Metil-CpG/genética; Regulação Alostérica; Animais; Sítios de Ligação; Química Encefálica; Cromatina/química; Clonagem Molecular; DNA/metabolismo; DNA (Citosina-5-)-Metiltransferases/química; DNA (Citosina-5-)-Metiltransferases/metabolismo; Metilação de DNA; DNA Metiltransferase 3A; Escherichia coli/genética; Escherichia coli/metabolismo; Expressão Gênica; Vetores Genéticos/química; Vetores Genéticos/metabolismo; Células HEK293; Histonas/química; Histonas/metabolismo; Humanos; Proteína 2 de Ligação a Metil-CpG/química; Proteína 2 de Ligação a Metil-CpG/metabolismo; Camundongos; Mutagênese Sítio-Dirigida/métodos; Ligação Proteica; Engenharia de Proteínas/métodos; Domínios e Motivos de Interação entre Proteínas; Proteínas Recombinantes/química; Proteínas Recombinantes/genética; Proteínas Recombinantes/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: DNA / Cromatina / Histonas / Epigênese Genética / DNA (Citosina-5-)-Metiltransferases / Proteína 2 de Ligação a Metil-CpG Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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