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Effect of oral fluconazole 1200 mg/day on QT interval in African adults with HIV-associated cryptococcal meningitis.
Molloy, Síle F; Bradley, John; Karunaharan, Natasha; Mputu, Muhammad; Stone, Neil; Phulusa, Jacob; Chawinga, Chimwemwe; Gaskell, Kate; Segula, Dalitso; Ming, Damien; Peirse, Mary; Chanda, Duncan; Lakhi, Shabir; Loyse, Angela; Kanyama, Cecilia; Heyderman, Robert S; Harrison, Thomas S.
Afiliação
  • Molloy SF; Centre for Global Health, Institute for Infection and Immunity, St George's University of London.
  • Bradley J; Joint first authors.
  • Karunaharan N; MRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, London, UK.
  • Mputu M; Joint first authors.
  • Stone N; Centre for Global Health, Institute for Infection and Immunity, St George's University of London.
  • Phulusa J; University Teaching Hospital, Lusaka, Zambia.
  • Chawinga C; University of Zambia School of Medicine, Lusaka, Zambia.
  • Gaskell K; Centre for Global Health, Institute for Infection and Immunity, St George's University of London.
  • Segula D; University of North Carolina Project-Malawi, Kamuzu Central Hospital, Lilongwe.
  • Ming D; University of North Carolina Project-Malawi, Kamuzu Central Hospital, Lilongwe.
  • Peirse M; Malawi-Liverpool-Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Malawi.
  • Chanda D; Malawi-Liverpool-Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Malawi.
  • Lakhi S; Malawi-Liverpool-Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Malawi.
  • Loyse A; Malawi-Liverpool-Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Malawi.
  • Kanyama C; University Teaching Hospital, Lusaka, Zambia.
  • Heyderman RS; University of Zambia School of Medicine, Lusaka, Zambia.
  • Harrison TS; University Teaching Hospital, Lusaka, Zambia.
AIDS ; 32(15): 2259-2261, 2018 09 24.
Article em En | MEDLINE | ID: mdl-30102652
ABSTRACT
We assessed the effect of fluconazole 1200 mg/day on the QT interval in cryptococcal meningitis patients. Mean corrected QT (QTc) change from baseline to day 7 was 10.1 ms (IQR -28 to 46 ms) in the fluconazole treatment group and -12.6 ms (IQR -39 to 13.5 ms) in those not taking fluconazole (P = 0.04). No significant increase in QTc measurements over 500 ms was observed with fluconazole. Nevertheless, it remains important to correct any electrolyte imbalance and avoid concomitant drugs that may increase QTc.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fluconazol / Infecções por HIV / Meningite Criptocócica / Sistema de Condução Cardíaco / Antifúngicos Tipo de estudo: Clinical_trials / Risk_factors_studies Limite: Adult / Humans País como assunto: Africa Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fluconazol / Infecções por HIV / Meningite Criptocócica / Sistema de Condução Cardíaco / Antifúngicos Tipo de estudo: Clinical_trials / Risk_factors_studies Limite: Adult / Humans País como assunto: Africa Idioma: En Ano de publicação: 2018 Tipo de documento: Article