Transport Mechanisms of Butyrate Modified Nanoparticles: Insight into "Easy Entry, Hard Transcytosis" of Active Targeting System in Oral Administration.

Wu, Lei; Bai, Yuli; Liu, Min; Li, Lian; Shan, Wei; Zhang, Zhirong; Huang, Yuan

Wu, Lei; Bai, Yuli; Liu, Min; Li, Lian; Shan, Wei; Zhang, Zhirong; Huang, Yuan.

Afiliação

Wu L; Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy , Sichuan University , No. 17, Block 3, Southern Renmin Road , Chengdu 610041 , P.R. China.
Bai Y; Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy , Sichuan University , No. 17, Block 3, Southern Renmin Road , Chengdu 610041 , P.R. China.
Liu M; Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy , Sichuan University , No. 17, Block 3, Southern Renmin Road , Chengdu 610041 , P.R. China.
Li L; Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy , Sichuan University , No. 17, Block 3, Southern Renmin Road , Chengdu 610041 , P.R. China.
Shan W; Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy , Sichuan University , No. 17, Block 3, Southern Renmin Road , Chengdu 610041 , P.R. China.
Zhang Z; Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy , Sichuan University , No. 17, Block 3, Southern Renmin Road , Chengdu 610041 , P.R. China.
Huang Y; Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy , Sichuan University , No. 17, Block 3, Southern Renmin Road , Chengdu 610041 , P.R. China.

Mol Pharm ; 15(9): 4273-4283, 2018 09 04.

Article em En | MEDLINE | ID: mdl-30102863

Assuntos

Administração Oral; Butiratos/química; Nanopartículas/química; Transcitose/fisiologia; Células CACO-2; Portadores de Fármacos/química; Sistemas de Liberação de Medicamentos/métodos; Exocitose/fisiologia; Humanos; Microscopia de Fluorescência

Palavras-chave

active targeting nanoparticles; bidirectional exocytosis; oral drug delivery; regulation of receptor distribution; surface hydrophobicity; transport mechanism; "easy entry, hard transcytosis"

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Butiratos / Administração Oral / Nanopartículas / Transcitose Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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