In Vitro Activities of the Benzoquinolizine Fluoroquinolone Levonadifloxacin (WCK 771) and Other Antimicrobial Agents against Mycoplasmas and Ureaplasmas in Humans, Including Isolates with Defined Resistance Mechanisms.
Antimicrob Agents Chemother
; 62(11)2018 11.
Article
em En
| MEDLINE
| ID: mdl-30104279
ABSTRACT
Levonadifloxacin (WCK 771) was evaluated against 68 type strains and clinical isolates of Mycoplasma genitalium, Mycoplasma hominis, Mycoplasma pneumoniae, and Ureaplasma spp. in comparison with moxifloxacin, levofloxacin, tetracycline, and azithromycin or clindamycin. Levonadifloxacin MICs were ≤0.5 µg/ml for M. genitalium MIC90s were 1 µg/ml for M. hominis, 0.125 µg/ml for M. pneumoniae, and 2 µg/ml for Ureaplasma spp. Levonadifloxacin merits further study for treating infections caused by these organisms.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ureaplasma
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Mycoplasma hominis
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Fluoroquinolonas
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Farmacorresistência Bacteriana
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Mycoplasma genitalium
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Antibacterianos
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article