TNF-&#945; elicits phenotypic and functional alterations of vascular smooth muscle cells by miR-155-5p-dependent down-regulation of cGMP-dependent kinase 1.

Choi, Seunghwan; Park, Minsik; Kim, Joohwan; Park, Wonjin; Kim, Suji; Lee, Dong-Keon; Hwang, Jong Yun; Choe, Jongseon; Won, Moo-Ho; Ryoo, Sungwoo; Ha, Kwon-Soo; Kwon, Young-Guen; Kim, Young-Myeong

TNF-α elicits phenotypic and functional alterations of vascular smooth muscle cells by miR-155-5p-dependent down-regulation of cGMP-dependent kinase 1.

Choi, Seunghwan; Park, Minsik; Kim, Joohwan; Park, Wonjin; Kim, Suji; Lee, Dong-Keon; Hwang, Jong Yun; Choe, Jongseon; Won, Moo-Ho; Ryoo, Sungwoo; Ha, Kwon-Soo; Kwon, Young-Guen; Kim, Young-Myeong.

Afiliação

Choi S; From the Departments of Molecular and Cellular Biochemistry.
Park M; From the Departments of Molecular and Cellular Biochemistry.
Kim J; From the Departments of Molecular and Cellular Biochemistry.
Park W; From the Departments of Molecular and Cellular Biochemistry.
Kim S; From the Departments of Molecular and Cellular Biochemistry.
Lee DK; From the Departments of Molecular and Cellular Biochemistry.
Hwang JY; Obstetrics and Gynecology.
Choe J; Immunology, and.
Won MH; Neurobiology, Kangwon National University School of Medicine, Chuncheon, Gangwon-do 24341.
Ryoo S; the Department of Biology, College of Natural Sciences, Kangwon National University, Chuncheon, Gangwon-do 24341, and.
Ha KS; From the Departments of Molecular and Cellular Biochemistry.
Kwon YG; the Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, South Korea.
Kim YM; From the Departments of Molecular and Cellular Biochemistry, ymkim@kangwon.ac.kr.

J Biol Chem ; 293(38): 14812-14822, 2018 09 21.

Article em En | MEDLINE | ID: mdl-30104414

Assuntos

Proteína Quinase Dependente de GMP Cíclico Tipo I/metabolismo; Regulação para Baixo/fisiologia; MicroRNAs/fisiologia; Músculo Liso Vascular/citologia; Fator de Necrose Tumoral alfa/fisiologia; Regiões 3' não Traduzidas; Actinas/metabolismo; Animais; Movimento Celular; Proliferação de Células; Células Cultivadas; Proteína Quinase Dependente de GMP Cíclico Tipo I/genética; Proteínas Quinases Dependentes de GMP Cíclico/metabolismo; Masculino; Camundongos Endogâmicos C57BL; Músculo Liso Vascular/enzimologia; Músculo Liso Vascular/metabolismo; NF-kappa B/metabolismo; Polimerização; RNA Mensageiro/genética

Palavras-chave

NF-kappa B (NF-κB); cGMP-dependent protein kinase 1; microRNA (miRNA); protein kinase G (PKG); tumor necrosis factor (TNF); vascular smooth muscle cells

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regulação para Baixo / Fator de Necrose Tumoral alfa / MicroRNAs / Proteína Quinase Dependente de GMP Cíclico Tipo I / Músculo Liso Vascular Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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