Small structural changes of the imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitors produce an improved safety profile.
Medchemcomm
; 8(4): 771-779, 2017 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-30108796
ABSTRACT
Small molecule DGAT2 inhibitors have shown promise for the treatment of metabolic diseases in preclinical models. Herein, we report the first toxicological evaluation of imidazopyridine-based DGAT2 inhibitors and show that the arteriopathy associated with imidazopyridine 1 can be mitigated with small structural modifications, and is thus not mechanism related.
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MEDLINE
Idioma:
En
Ano de publicação:
2017
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Article