Principles of Ubiquitin-Dependent Signaling.
Annu Rev Cell Dev Biol
; 34: 137-162, 2018 10 06.
Article
em En
| MEDLINE
| ID: mdl-30110556
ABSTRACT
Ubiquitylation is an essential posttranslational modification that controls cell division, differentiation, and survival in all eukaryotes. By combining multiple E3 ligases (writers), ubiquitin-binding effectors (readers), and de-ubiquitylases (erasers) with functionally distinct ubiquitylation tags, the ubiquitin system constitutes a powerful signaling network that is employed in similar ways from yeast to humans. Here, we discuss conserved principles of ubiquitin-dependent signaling that illustrate how this posttranslational modification shapes intracellular signaling networks to establish robust development and homeostasis throughout the eukaryotic kingdom.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Processamento de Proteína Pós-Traducional
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Ubiquitina
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Ubiquitinação
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article