Histopathological differences of experimental aneurysms treated with bare platinum, fibered, and bioactive coils.
Minim Invasive Ther Allied Technol
; 28(3): 172-177, 2019 Jun.
Article
em En
| MEDLINE
| ID: mdl-30113870
ABSTRACT
PURPOSE:
To evaluate the histopathological features of experimental aneurysms embolized with bare platinum, fibered, and bioactive coils. MATERIAL ANDMETHODS:
Twelve experimental aneurysms were constructed in three swine. The aneurysms were divided into four groups and were embolized using a bare platinum coil alone (P group, n = 2), a bioactive coil alone (B group, n = 2), a combination of fibered and bare platinum coils (F/P group, n = 4) and a combination of fibered and bioactive coils (F/B group, n = 4). Histopathological data for all aneurysms recorded at 63 days were analyzed in terms of neointima formation, fibrosis, foreign-body giant-cell infiltration, and organization.RESULTS:
Fibrosis was significantly greater in group B compared with that in group F/P (p = .02).ã Inflammation with foreign-body giant-cell infiltration was significantly greater in groups F/P and F/B compared with that in groups P and B (p = .007).CONCLUSION:
The present study revealed that the embolic effect of fibered coils was not a thrombus but instead was a foreign-body response in the chronic phase.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Platina
/
Aneurisma Intracraniano
/
Embolização Terapêutica
Limite:
Animals
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article