2,4-Dimethylaniline generates phosphorylated histone H2AX in human urothelial and hepatic cells through reactive oxygen species produced by cytochrome P450 2E1.

Qi, Yonggang; Toyooka, Tatsushi; Kashiwagi, Hiroki; Yanagiba, Yukie; Koda, Shigeki; Ohta, Hisayoshi; Wang, Rui-Sheng

Qi, Yonggang; Toyooka, Tatsushi; Kashiwagi, Hiroki; Yanagiba, Yukie; Koda, Shigeki; Ohta, Hisayoshi; Wang, Rui-Sheng.

Afiliação

Qi Y; Industrial Toxicology and Health Effects Research Group, National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-ku, Kawasaki, Kanagawa, 214-8585, Japan.
Toyooka T; Department of Environmental, Occupational Health and Toxicology, Graduate School of Medical Sciences, Kitasato University, Tokyo, Japan.
Kashiwagi H; Industrial Toxicology and Health Effects Research Group, National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-ku, Kawasaki, Kanagawa, 214-8585, Japan. toyooka@h.jniosh.johas.go.jp.
Yanagiba Y; Industrial Toxicology and Health Effects Research Group, National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-ku, Kawasaki, Kanagawa, 214-8585, Japan.
Koda S; Industrial Toxicology and Health Effects Research Group, National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-ku, Kawasaki, Kanagawa, 214-8585, Japan.
Ohta H; Industrial Toxicology and Health Effects Research Group, National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-ku, Kawasaki, Kanagawa, 214-8585, Japan.
Wang RS; Department of Environmental, Occupational Health and Toxicology, Graduate School of Medical Sciences, Kitasato University, Tokyo, Japan.

Arch Toxicol ; 92(10): 3093-3101, 2018 10.

Article em En | MEDLINE | ID: mdl-30132044

Assuntos

Compostos de Anilina/toxicidade; Família 2 do Citocromo P450/metabolismo; Hepatócitos/efeitos dos fármacos; Histonas/metabolismo; Espécies Reativas de Oxigênio/metabolismo; Ciclo Celular/efeitos dos fármacos; Células Cultivadas; Inibidores do Citocromo P-450 CYP2E1/farmacologia; Quebras de DNA de Cadeia Dupla/efeitos dos fármacos; Células Epiteliais/efeitos dos fármacos; Hepatócitos/metabolismo; Humanos; Fosforilação/efeitos dos fármacos; Ureter/citologia

Palavras-chave

2,4-Dimethylaniline; Cytochrome P450 2E1; Genotoxicity; Phosphorylated histone H2AX; Reactive oxygen species

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Histonas / Espécies Reativas de Oxigênio / Hepatócitos / Família 2 do Citocromo P450 / Compostos de Anilina Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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