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MAIT cells protect against pulmonary Legionella longbeachae infection.
Wang, Huimeng; D'Souza, Criselle; Lim, Xin Yi; Kostenko, Lyudmila; Pediongco, Troi J; Eckle, Sidonia B G; Meehan, Bronwyn S; Shi, Mai; Wang, Nancy; Li, Shihan; Liu, Ligong; Mak, Jeffrey Y W; Fairlie, David P; Iwakura, Yoichiro; Gunnersen, Jennifer M; Stent, Andrew W; Godfrey, Dale I; Rossjohn, Jamie; Westall, Glen P; Kjer-Nielsen, Lars; Strugnell, Richard A; McCluskey, James; Corbett, Alexandra J; Hinks, Timothy S C; Chen, Zhenjun.
Afiliação
  • Wang H; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, 3010, Australia.
  • D'Souza C; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, 3010, Australia.
  • Lim XY; Centre for Animal Biotechnology, Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Melbourne, VIC, 3010, Australia.
  • Kostenko L; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, 3010, Australia.
  • Pediongco TJ; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, 3010, Australia.
  • Eckle SBG; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, 3010, Australia.
  • Meehan BS; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, 3010, Australia.
  • Shi M; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, 3010, Australia.
  • Wang N; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, 3010, Australia.
  • Li S; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, 3010, Australia.
  • Liu L; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, 3010, Australia.
  • Mak JYW; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, University of Melbourne, Parkville, VIC, 3010, Australia.
  • Fairlie DP; Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia.
  • Iwakura Y; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, The University of Queensland, Brisbane, QLD, 4072, Australia.
  • Gunnersen JM; Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia.
  • Stent AW; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, The University of Queensland, Brisbane, QLD, 4072, Australia.
  • Godfrey DI; Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia.
  • Rossjohn J; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, The University of Queensland, Brisbane, QLD, 4072, Australia.
  • Westall GP; Center for Animal Disease Models, Research Institute for Biomedical Sciences, Tokyo University of Science, Chiba-ken, 278-8510, Japan.
  • Kjer-Nielsen L; Anatomy and Neuroscience Department, University of Melbourne, Melbourne, VIC, 3000, Australia.
  • Strugnell RA; Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Melbourne, VIC, 3000, Australia.
  • McCluskey J; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, 3010, Australia.
  • Corbett AJ; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, University of Melbourne, Parkville, VIC, 3010, Australia.
  • Hinks TSC; Infection and Immunity Program and the Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia.
  • Chen Z; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, VIC, 3800, Australia.
Nat Commun ; 9(1): 3350, 2018 08 22.
Article em En | MEDLINE | ID: mdl-30135490
Mucosal associated invariant T (MAIT) cells recognise conserved microbial metabolites from riboflavin synthesis. Striking evolutionary conservation and pulmonary abundance implicate them in antibacterial host defence, yet their functions in protection against clinically important pathogens are unknown. Here we show that mouse Legionella longbeachae infection induces MR1-dependent MAIT cell activation and rapid pulmonary accumulation of MAIT cells associated with immune protection detectable in immunocompetent host animals. MAIT cell protection is more evident in mice lacking CD4+ cells, and adoptive transfer of MAIT cells rescues immunodeficient Rag2-/-γC-/- mice from lethal Legionella infection. Protection is dependent on MR1, IFN-γ and GM-CSF, but not IL-17A, TNF or perforin, and enhanced protection is detected earlier after infection of mice antigen-primed to boost MAIT cell numbers before infection. Our findings define a function for MAIT cells in protection against a major human pathogen and indicate a potential role for vaccination to enhance MAIT cell immunity.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Legionella longbeachae / Células T Invariantes Associadas à Mucosa / Pulmão Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Legionella longbeachae / Células T Invariantes Associadas à Mucosa / Pulmão Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article