Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies.
Nat Commun
; 9(1): 3361, 2018 08 22.
Article
em En
| MEDLINE
| ID: mdl-30135514
ABSTRACT
Currently available influenza virus vaccines have inadequate effectiveness and are reformulated annually due to viral antigenic drift. Thus, development of a vaccine that confers long-term protective immunity against antigenically distant influenza virus strains is urgently needed. The highly conserved influenza virus hemagglutinin (HA) stalk represents one of the potential targets of broadly protective/universal influenza virus vaccines. Here, we evaluate a potent broadly protective influenza virus vaccine candidate that uses nucleoside-modified and purified mRNA encoding full-length influenza virus HA formulated in lipid nanoparticles (LNPs). We demonstrate that immunization with HA mRNA-LNPs induces antibody responses against the HA stalk domain of influenza virus in mice, rabbits, and ferrets. The HA stalk-specific antibody response is associated with protection from homologous, heterologous, and heterosubtypic influenza virus infection in mice.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Orthomyxoviridae
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RNA Mensageiro
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Virus da Influenza A Subtipo H5N1
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Hemaglutininas
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Anticorpos Antivirais
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article